Glycine is an inhibitory neurotransmitter that supports relaxation and healthy stress management.* It also enhances detoxification by increasing glutathione production.*

The amino acid glycine plays a key role in maintaining a healthy central nervous system (CNS).* It is considered one of the most important inhibitory neurotransmitters in the CNS, particularly in the brainstem and spinal cord.* Studies show glycine can help improve memory retrieval in individuals with a wide variety of sleep-depriving conditions, such as jet lag and overwork.* The benefits of glycine are not just limited to the CNS. Glycine also plays a key role in phase II liver detoxification by having a direct effect on toxin elimination or by increasing the level of glutathione.* Glycine also helps modulate cytokines associated with obesity.*

Glycine is one of three amino acids needed to produce creatine, which in turn supplies energy to muscle and nerve cells.* The other two amino acids are arginine and methionine. High concentrations of glycine are found in the muscles, the skin, and other connective tissues. Approximately 30 percent of collagen is composed of glycine.

Glycine plays an important role in supporting a healthy digestive system by helping to regulate the synthesis of bile acid, which the body uses to digest fats.* Glycine also plays a role in regulating the utilization of glucose during energy production.*

Thorne's Melaton-3 is NSF Certified for Sport®. Thorne offers melatonin in both 3 mg (Melatonin-3) and 5 mg (Melatonin-5) capsules. Melatonin, the primary hormone of the pineal gland, is a powerful "chronobiotic" that helps maintain the body's normal circadian rhythms.* In individuals who have difficulty sleeping or who have altered circadian rhythms because of jet lag or night shift work, melatonin supplementation promotes the resynchronization of this cycle.* Supplementation can also benefit those whose difficulty sleeping is caused by the aging-related decrease in the body's ability to synthesize melatonin from the amino acid tryptophan.* Research indicates melatonin exerts its sleep-promoting efficacy by decreasing the amount of time needed to fall asleep, by promoting the ability to stay asleep, and by enhancing the depth of sleep.*

Melatonin administration from 0.3 mg to 5.0 mg has been shown to exert a sedative-like effect.* When supplemented prior to the onset of the body's normal melatonin secretion, even a low amount of melatonin can promote sleep.* Melatonin apparently enhances the effect of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors, thus resulting in relaxation.* Thorne's Melaton-3 supplies three mg of melatonin in each capsule, and Melaton-5 supplies 5 mg per capsule and is used when a higher amount of melatonin is desired. Melatonin also has significant antioxidant activity.* Adequate melatonin levels have been reported to be a positive factor in cardiovascular, neuroendocrine, GI, and bone health.*

Because an athlete needs to know that his or her supplements are trustworthy and compliant, every batch of an NSF Certified for Sport® product is tested for compliance with label claims and to ensure the absence of more than 200 substances banned by many major athletic organizations, including stimulants, narcotics, steroids, diuretics, beta-2 agonists, and masking agents.

Gamma-aminobutyric acid (GABA) is a major calming brain chemical or neurotransmitter.* Clinical studies show that the natural form of GABA that is in Thorne's PharmaGABA can decrease the brain's stress-related beta waves and increase the production of its alpha-waves, creating a profound sense of physical relaxation while maintaining mental focus.* Other studies have shown reduced pupil diameter, heart rate, and two natural biomarkers of stress – salivary cortisol and chromogranin A – all signs of relaxation.* In addition, studies also indicate GABA can enhance sleep.* In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, the synthetic GABA did not demonstrate these positive effects.* PharmaGABA-250 offers 250 mg of natural GABA per capsule, while PharmaGABA-100 offers 100 mg per capsule. Both are non-habit forming.

In a recent study of the effect of nutrient supplementation on muscle mass, 21 males, average age 39, who did not exercise regularly, were given 10 grams of whey protein or 10 grams of whey protein plus 100 mg of PharmaGABA daily for 12 weeks. Both groups participated in twice weekly 60-minute strength training sessions that consisted of leg presses, leg extensions, leg curls, chest presses, and pull-downs. Total body lean muscle mass increased significantly in the whey protein-plus-PharmaGABA group compared to the whey-only group.*

The natural GABA in Thorne's PharmaGABA suite is produced via a fermentation process that utilizes Lactobacillus hilgardii, the same bacteria that is used to ferment cabbage in the preparation of the traditional Korean dish known as kimchi.

PS 150 features 150 mg of non-soy, sunflower-sourced phosphatidylserine (PS) per capsule. PS is a nutrient that is essential for supporting brain health.* As PS is difficult to obtain solely from the diet, supplementation may be warranted for certain individuals.

Calming Cream™ was designed by a leading neuroimmune specialist to provide maximum transdermal delivery of GABA, L-Theanine, 5-HTP and Magnesium in a lotion base of lavender oil.

Calming Cream may naturally assist with:

• Relaxation*
• Nervousness*
• Mood*
• Hyperactivity*
• Occasional sleeplessness*

This topical cream is designed to naturally increase the levels of the calming reducing neurotransmitters in the brain such as dopamine, GABA and serotonin.